Features of lymph node metastasis depending on intratumoral heterogeneity of non-small cell lung cancer in patients with different morphological changes in the bronchial epithelium

The aim of the study: to examine relationship between morphological diversity non-small cell lung cancer and frequency lymph node metastasis in groups patients with different epithelial conditions bronchi adjacent tumor. Material methods. Surgical specimens from 90 cancer, who were treated Thoracoabdominal Department Of Research Institute Oncology Tomsk National Medical Center period 2009 2017 studied. histological type was determined according classification (2020). Lepidic, acinar, papillary, micropapillary, solid solitary tumor cells isolated parenchymal component adenocarcinoma. In squamous carcinoma, 5 types structures distinguished: keratinization, consisting atypical prickly without basaloid type, built pronounced polymorphism, single cells. Results. basal hyperplasia, acinar (37 %), papillary (29 %) (27 patterns found less frequently cases metastatic regional nodes compared those (63 %; p=0.05; 71 73 p=0.01, respectively). hyperplasia bronchial epithelium, presence 1 (with keratinization) (17 2 (spiky pattern) (33 4 (polymorphic detected metastases (83 p=0.01; 67 p=0.02 a combination metaplasia, spiny pattern (65 (100 polymorphic (82 (89 more than (35 р=0.04; 0 р=0.01; 18 11 р=0.01, Conclusion. data obtained clarify available information on significance heterogeneity for predicting course adenocarcinoma carcinoma lung.